Figure 4

Effects on network structure at 10% deletion rate. The figures shows the fraction of edges remaining (FER) after deleting the 10% most highly connected nodes (top) as well as the resulting number of connected components (NCR) (bottom). Results are shown for all PPI networks examined and the corresponding reference networks and networks are sorted according to the correlation coefficient in the original PPI networks. Both network characteristics show that negatively correlated networks are most vulnerable to targeted deletion. Furthermore, the original PPI networks behave most similar to the uncorrelated references. Differences in NCR between different PPI networks are due to differences in network size.