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Figure 1 | BMC Bioinformatics

Figure 1

From: Exploring inconsistencies in genome-wide protein function annotations: a machine learning approach

Figure 1

Distribution of Ser/Thr, Tyr, and dual specificity kinases among annotated protein kinases in human versus mouse genomes [see Additional file 9]. Pie charts illustrate the functional family distribution of protein kinases in human (top) versus mouse (bottom), based on: a. AmiGO functional classifications: Ser/Thr (GO0004674) [Blue]; Tyr (GO0004713) [Red] or "dual specificity" (proteins with both GO classifications) [Yellow]. b. UniProt annotations: classification based on UniProt records containing the key words Ser/Thr [Blue], Tyr [Red], or dual specificity [Yellow] [see Additional file 2]. c. Predicted annotations by the HDTree classifier: The classifier was built on human proteins with functional labels Ser/Thr (GO0004674) [Blue], Tyr (GO0004713) [Red] or "dual specificity" [Yellow] derived from AmiGO and verified by UniProt [see Additional file 4].

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