Table 2 Functional comparison of TMs constructed by ECIM and GRAM. Several key Gene Ontologies were implicated by both algorithms (bold text with matching numbers).
FDR adjusted p-value | GO categories associated with ECIM modules | GO categories associated with GRAM modules | FDR adjusted p-value |
|---|---|---|---|
2.7E-57 | protein biosynthesis (1) | oxidative phosphorylation | 9.9E-12 |
2.1E-39 | ribosome biogenesis and assembly | amino acid metabolism (5) | 2.9E-10 |
1.6E-17 | meiosis | protein biosynthesis (1) | 4.7E-09 |
1.6E-16 | spore wall assembly (sensu Fungi) (2) | Sporulation (2) | 3.7E-08 |
1.4E-15 | sulfur metabolism (3) | sulfur metabolism (3) | 2.3E-07 |
1.2E-07 | spore wall assembly (sensu Fungi) (2) | protein biosynthesis (1) | 3.3E-06 |
1.8E-07 | DNA replication | protein biosynthesis (1) | 8.8E-06 |
2.7E-07 | arginine biosynthesis | Glycolysis | 6.8E-05 |
5.7E-06 | ribosome biogenesis | protein biosynthesis (1) | 1.3E-04 |
1.5E-03 | mitosis (4) | de novo' IMP biosynthesis | 6.1E-04 |
2.4E-03 | lagging strand elongation | chromatin assembly or disassembly | 1.6E-03 |
4.7E-03 | amino acid biosynthesis (5) | sulfur metabolism (3) | 6.8E-03 |
1.0E-02 | mitotic cell cycle (4) | alcohol catabolism | 7.3E-03 |
1.6E-02 | cytokinesis, completion of separation | interphase of mitotic cell cycle (4) | 1.2E-02 |
3.6E-02 | protein neddylation | mitotic sister chromatid cohesion (4) | 1.4E-02 |