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Table 1 Empirical type I error rates and powers of the proposed (T s ) and Zhao et al's (T z ) tests, and average percentages of perfectly estimated haplotypes for the dominant and recessive models according to 4 types of haplotype distribution (HD)

From: Haplotype-based score test for linkage in nuclear families

  

Dominant

Recessive

HD

RR

p f

p o

T s

T z

p f

p o

T s

T z

E

1

88

72

.060

.065

88

72

.045

.050

 

2

88

73

.275

.280

88

72

.145

.110

 

3

88

73

.635

.645

89

73

.275

.275

 

4

89

74

.815

.820

89

72

.455

.460

UE1

1

92

79

.060

.065

92

79

.050

.040

 

2

92

79

.240

.235

92

79

.060

.050

 

3

92

79

.560

.545

92

79

.050

.055

 

4

92

79

.845

.840

93

79

.065

.055

UE2

1

99

94

.050

.065

99

94

.075

.085

 

2

98

92

.270

.250

99

93

.035

.040

 

3

98

90

.610

.580

99

93

.065

.055

 

4

97

89

.885

.860

99

93

.065

.060

UE3

1

100

100

.040

.055

100

100

.090

.075

 

2

100

100

.375

.325

100

100

.055

.065

 

3

100

100

.795

.780

100

100

.060

.055

 

4

100

100

.960

.950

100

100

.070

.060

  1. The rows corresponding to RR = 1 are for type I error rate, and the rows corresponding to RR = 2, 3 or 4 are for power. The columns corresponding to p f and p o are the average percentages of perfectly estimated haplotypes, respectively, when based on family trios and based on parents alone in estimating haplotype frequencies.
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BMC Bioinformatics

ISSN: 1471-2105

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