Semantic integration to identify overlapping functional modules in protein interaction networks

BMC Bioinformatics

Table 1 Accuracy of output modules by the flow-based method

weighting scheme	modules before post-processing		modules after post-processing
	-log(p-value)	f-measure	-log(p-value)	f-measure
semantic similarity	24.10	0.334	24.42	0.337
semantic interactivity	28.58	0.399	29.05	0.401
genetic co-expression	17.66	0.268	17.42	0.267

The output modules were generated by the flow-based algorithm with 200 informative proteins. The input was the protein interaction networks weighted by three metrics. For each metric, the average values of -log(p-value) and f-measure of the output modules were calculated before and after the post-processing step to merge similar modules.

ISSN: 1471-2105