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Table 5 Correspondence between protein and mRNA level sequence changes. Pre-mRNAs can be alternatively spliced in several ways [53] [54]. The corresponding sequence changes map only to two types of sequence changes at protein level: substitutions and/or insertions/deletions. In this table we show the ten most frequent types of pre-mRNA AS (first column) and the corresponding protein sequence changes (second and third columns). The former where obtained from the work of Nagasaki and colleagues [54], after grouping some of their types, and are described using a notation similar to that used by Zheng and coworkers [53].

From: A procedure for identifying homologous alternative splicing events

AS type

Insertion/deletion

Substitution

Alternative transcriptional initiation

No

Yes

Exon skipping

If exon size is multiple of 3

If frameshift changes

Alternate polyadenilation site

No

Yes

Intron retention

If intron size is multiple of 3

If frameshift changes

Alternative acceptor

If frameshift is preserved

If frameshift changes

Alternative donor

If frameshift is preserved

If frameshift changes

Multiple exon skipping

If global exon size is multiple of 3

If frameshift changes

Mutually exclusive exons

No

Yes

Complex Alternative donor/Exon skipping or Alternative acceptor/Exon skipping

If frameshift is preserved

If frameshift changes

Complex Multiple exon skipping/Alternate polyadenilation site

No

Yes