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Figure 5 | BMC Bioinformatics

Figure 5

From: A procedure for identifying homologous alternative splicing events

Figure 5

Example of false positive. The figure shows two AS events constituted by one long and one short isoform each. One is from human ATP2B3, the other from rat Atp2b3. These two events are not homologous, although our method predicts them as such. This is probably because the human long/mouse long and human short/mouse short isoform pairings have much better values of the scoring parameters than the human long/mouse short and human short/mouse long pairings. Dotted lines between isoforms indicate sequence stretches substituted between isoforms in each species. Black: protein sequence adjacent to the AS sequence change. Blue: substituted sequence stretch from the long isoform. Red: sequence stretch from the short isoform substituted only in human. Yellow: sequence stretch from the short isoform substituted in both species. Light grey: remaining of the protein, where a second and identical AS sequence change takes place in both species.

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