Figure 2

Local and global sequence identities. This figure illustrates how we computed these properties. Global sequence identity is the ratio between the total number of identical residue pairs in the alignment divided by the total number of aligned pairs. Local sequence identity is computed relative to the sequence stretch in the target isoform (upper sequence, red bold characters) modified by alternative splicing, and is equal to the number of identical residue pairs involving residues from this stretch, divided by the size of the stretch (the part of the alignment involved in computing local sequence identity is enclosed within a red box and shaded in light blue).