Figure 3

Average frequency of iPfam domain pairs relative to degree of node. Each point represents a protein in the interaction networks of H. sapiens (blue) and S. cerevisiae (green). For each protein, we calculate the degree, defined as the number of interactions the protein is involved in. On the y-axis, we show the average number of i Pfam domain pairs in edges adjacent to proteins of degree x. We calculated a Spearman correlation of 0.68 and 0.71, for H. sapiens and S. cerevisiae. The correlation is outlined by dotted lines.