Figure 9

Pavlidis Template Matching (PTM). Four PTM templates were created. For each template, the standardized signal intensity average of all genes that fit the template are plotted by subject along with a superimposed template to which they were correlated. A. The 'monotonic increase' template matches two StatiGen-identified patterns, 1100 and 100 (Fig. 6). B. Young to Mid-Age increase corresponds to pattern 110 (Fig. 6). C. Young to Mid-Age decrease corresponds to pattern -110 (Fig. 6)- the mirror reflection of pattern 110. D. Mid-Age to Age increase corresponds to pattern 1100 (Fig. 6). Genes in each pattern were tested for overrepresentation of Biological Processes in the Gene Ontology using DAVID (see Methods). Selected overrepresented categories are listed in each panel. Inset: High degree of overlap between A, B, and D, with the three templates identifying similar sets of genes (by overrepresentation analysis, humoral immune response genes could not be distinguished among the three templates).