Table 1 Essential Complexes. Selected essential complexes from the E-2 complex set. Complexes listed are composed of at least 4 subunits, of which >70% are essential. For each complex, the table lists the E-2 complex identifier, the size of the complex, the fraction of essential proteins, the most significant GO cellular component annotation for the complex, and the list of proteins in the complex. Twenty-six percent of all essential genes in yeast are represented in these complexes
From: A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality
Complex ID | Size | % Essentia l | Most significantly enriched GO CC term | Complex members |
|---|---|---|---|---|
C1 | 35 | 74% | DNA-directed RNA polymerase III complex | DST1, IWR1, RET1, RPA12, RPA135, RPA14, RPA190, RPA34, RPA43, RPA49, RPB10, RPB11, RPB2, RPB3, RPB4, RPB5, RPB7, RPB8, RPB9, RPC11, RPC17, RPC19, RPC25, RPC31, RPC34, RPC37, RPC40, RPC53, RPC82, RPO21, RPO26, RPO31, SPT4, TFG1, TFG2 |
C4 | 27 | 93% | small nucleolar ribonucleoprotein complex | BMS1, DIP2, ECM16, EMG1, IMP3, MPP10, NAN1, NOC4, NOP14, POL5, PWP2, SOF1, UTP10, UTP13, UTP14, UTP15, UTP18, UTP20, UTP21, UTP30, UTP4, UTP5, UTP6, UTP7, UTP8, UTP9, YGR210C |
C11 | 20 | 75% | mRNA cleavage and polyadenylation specificity factor complex | BUD14, CFT1, CFT2, FIP1, GIP3, GLC7, GLC8, MPE1, PAP1, PFS2, PTA1, PTI1, REF2, SDS22, SSU72, SWD2, SYC1, YPI1, YSH1, YTH1 |
C12 | 20 | 85% | U4/U6 × U5 tri-snRNP complex | AAR2, BRR2, DIB1, LEA1, LSM8, PRP11, PRP21, PRP3, PRP31, PRP38, PRP4, PRP6, PRP8, PRP9, RSE1, SMX2, SNU114, SNU23, SNU66, SPP381 |
C13 | 18 | 72% | proteasome core complex, alpha-subunit complex (sensu Eukaryota) | FLC2, GRH1, OSM1, PRE1, PRE10, PRE2, PRE3, PRE4, PRE5, PRE6, PRE7, PRE8, PRE9, PUP1, PUP2, PUP3, RED1, SCL1 |
C14 | 18 | 72% | snRNP U1 | BRR1, LUC7, MUD1, NAM8, PRP39, PRP40, PRP42, SMB1, SMD1, SMD2, SMD3, SME1, SMX3, SNP1, SNU56, SNU71, STO1, YHC1 |
C20 | 13 | 77% | (no significant annotation) | BRX1, CIC1, DRS1, ERB1, FPR4, HAS1, MAK5, NOC2, NOC3, PUF6, PWP1, RRP5, YTM1 |
C26 | 11 | 73% | eukaryotic translation initiation factor 2B complex | CDC123, GCD1, GCD11, GCD2, GCD6, GCD7, GCN3, PET111, SUI2, SUI3, YVH1 |
C30 | 10 | 90% | (no significant annotation) | EBP2, MRT4, NOG1, NOP15, NOP2, NOP7, NUG1, RLP7, RPF2, TIF6 |
C38 | 8 | 88% | nuclear pore | GLE2, NIC96, NSP1, NUP116, NUP159, NUP49, NUP57, NUP82 |
C41 | 8 | 88% | DASH complex | ASK1, DAD1, DAD2, DAD3, DAM1, DUO1, SPC19, SPC34 |
C42 | 8 | 100% | exocyst | EXO70, EXO84, SEC10, SEC15, SEC3, SEC5, SEC6, SEC8 |
C44 | 8 | 100% | (no significant annotation) | DBP10, NIP7, NSA1, RIX7, RPF1, RRP1, SPB1, SPB4 |
C46 | 7 | 86% | Arp2/3 protein complex | ARC15, ARC18, ARC19, ARC35, ARC40, ARP2, ARP3 |
C48 | 7 | 71% | DNA replication factor C complex | CTF18, ELG1, RFC1, RFC2, RFC3, RFC4, RFC5 |
C53 | 7 | 100% | transcription factor TFIIH complex | CCL1, KIN28, RAD3, SSL1, TFB1, TFB3, TFB4 |
C54 | 7 | 86% | signal recognition particle (sensu Eukaryota) | LHP1, SEC65, SRP14, SRP21, SRP54, SRP68, SRP72 |
C55 | 7 | 100% | nucleolar ribonuclease P complex | POP1, POP3, POP4, POP5, POP7, POP8, RPP1 |
C65 | 6 | 100% | nuclear origin of replication recognition complex | ORC1, ORC2, ORC3, ORC4, ORC5, ORC6 |
C67 | 6 | 100% | transcription factor TFIIIC complex | TFC1, TFC3, TFC4, TFC6, TFC7, TFC8 |
C72 | 6 | 83% | (no significant annotation) | DSL1, SEC22, SEC39, TIP20, UFE1, USE1 |
C74 | 6 | 100% | chaperonin-containing T-complex | CCT2, CCT3, CCT4, CCT5, CCT6, TCP1 |
C78 | 5 | 100% | (no significant annotation) | IPI1, IPI3, RIX1, RSA4, SDA1 |
C79 | 5 | 100% | nuclear cohesin complex | CDC5, IRR1, MCD1, SMC1, SMC3 |
C85 | 5 | 80% | GINS complex | CTF4, PSF1, PSF2, PSF3, SLD5 |
C86 | 5 | 100% | nuclear condensin complex | BRN1, SMC2, SMC4, YCG1, YCS4 |
C89 | 5 | 80% | nucleolar preribosome, small subunit precursor | ENP1, HRR25, LTV1, RIO2, TSR1 |
C101 | 4 | 100% | MIND complex | DSN1, MTW1, NNF1, NSL1 |
C106 | 4 | 100% | alpha DNA polymerase:primase complex | POL1, POL12, PRI1, PRI2 |
C110 | 4 | 75% | (no significant annotation) | CIA1, MET18, NAR1, YHR122W |
C111 | 4 | 75% | (no significant annotation) | NAB3, NAB6, NRD1, SEN1 |
C115 | 4 | 100% | mRNA cleavage factor complex | CLP1, PCF11, RNA14, RNA15 |
C124 | 4 | 75% | transcription factor TFIIE complex | DBP2, PPN1, TFA1, TFA2 |
C92 | 4 | 75% | outer plaque of spindle pole body | SPC72, SPC97, SPC98, TUB4 |
C93 | 4 | 100% | Ndc80 complex | NUF2, SPC24, SPC25, TID3 |