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Figure 6 | BMC Bioinformatics

Figure 6

From: Gene network interconnectedness and the generalized topological overlap measure

Figure 6

Separation of protein biosynthesis genes from non-protein biosynthesis genes in perturbed versions of the yeast network. The average separation (c.f. Eq. 6) is reported for GTOM0 (red), GTOM1 (green), GTOM2 (blue) and GTOM3 (brown). To assess the robustness of the GTOM measures to random deletions, we randomly deleted a proportion p of connections (adjacencies) and averaged the results across 20 draws. Note that GTOM2 outperforms the other measures if p < 67%. GTOM3 outperforms GTOM2 if more than 67% of adjacencies are deleted. This illustrates that high values of m can counter the effect of misspecified (unknown or missing) adjacencies.

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