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Table 4 Hinge frequency of occurrence in various physicochemical classifications

From: Hinge Atlas: relating protein sequence to sites of structural flexibility

Category

Amino acids

Hinge Residues (count)

All residues (count)

Hinge Residues (expected)

HI

P-value

Aliphatic

I, L, V

144

11915

190

-0.120

5.9·10-05

Aromatic

H, F, W, Y

82

5718

91

-0.0454

0.14

 

A, C, G, H, I, L, K,

     

Hydrophobic

M, F, T, W, Y, V

521

35278

562

-0.0326

0.0023

Negative

D, E

102

6774

108

-0.0242

0.29

Charged

R, D, E, H, Y

212

13931

227

-0.0196

0.24

Positive

R, H, Y

110

7157

114

-0.0153

0.37

 

R, N, D, E, Q, H, Y,

     

Polar

S, T, W, Y

488

29427

468

0.0178

0.096

 

A, N, D, C, G, P, S,

     

Small

T, V

502

28430

453

0.0450

0.00041

Tiny

G, A, S

253

12247

195

0.113

0.0000023