Re-sampling strategy to improve the estimation of number of null hypotheses in FDR control under strong correlation structures

Lu, Xin; Perkins, David L

doi:10.1186/1471-2105-8-157

Table 1 Mean Square Error of π₀ estimation by different methods

From: Re-sampling strategy to improve the estimation of number of null hypotheses in FDR control under strong correlation structures

	Data_B												Data_M
ρ	0.3				0.5				0.7
True π₀	0.9	0.8	0.7	0.6	0.9	0.8	0.7	0.6	0.9	0.8	0.7	0.6	0.9	0.8	0.7	0.6
Bootstrap	0.0038	0.0029	0.0035	0.0030	0.0106	0.0113	0.0115	0.0105	0.0423	0.0495	0.0422	0.0336	0.0202	0.0227	0.0213	0.0164
Qvalue	0.0045	0.0054	0.0051	0.0049	0.0120	0.0190	0.0170	0.0139	0.0445	0.0592	0.0621	0.0622	0.0247	0.0309	0.0318	0.0214
SPLOSH	0.0061	0.0059	0.0119	0.0201	0.0233	0.0107	0.0173	0.0308	0.0909	0.0456	0.0279	0.0298	0.0239	0.0145	0.0225	0.0388
BUM	0.0040	0.0032	0.0032	0.0040	0.0042	0.0037	0.0045	0.0061	0.0097	0.0050	0.0060	0.0060	0.0041	0.0071	0.0090	0.0117
Convest	0.0018	0.0021	0.0024	0.0021	0.0076	0.0087	0.0079	0.0076	0.0367	0.0402	0.0339	0.0275	0.0177	0.0200	0.0173	0.0138
PRE	0.0063	0.0072	0.0103	0.0151	0.0135	0.0189	0.0249	0.0402	0.0690	0.0739	0.0746	0.0748	0.0225	0.0289	0.0343	0.0478
Mgf	0.0017	0.0026	0.0038	0.0039	0.0054	0.0060	0.0048	0.0043	0.0122	0.0152	0.0148	0.0130	0.0104	0.0114	0.0094	0.0076
Adaptive	0.0030	0.0075	0.0144	0.0175	0.0008	0.0017	0.0023	0.0028	0.0012	0.0024	0.0025	0.0019	0.0003	0.0005	0.0005	0.0010
SampG.q Q2	0.0017	0.0026	0.0035	0.0032	0.0059	0.0067	0.0054	0.0049	0.0135	0.0168	0.0162	0.0140	0.0114	0.0124	0.0103	0.0085
SampG.q Q3	0.0043	0.0069	0.0084	0.0077	0.0065	0.0100	0.0076	0.0062	0.0106	0.0163	0.0176	0.0160	0.0109	0.0137	0.0119	0.0091
SampS.q Q2	0.0017	0.0026	0.0036	0.0033	0.0062	0.0070	0.0055	0.0051	0.0138	0.0176	0.0169	0.0169	0.0138	0.0136	0.0122	0.0094
SampS.q Q3	0.0046	0.0072	0.0091	0.0083	0.0073	0.0139	0.0110	0.0091	0.0081	0.0233	0.0341	0.0384	0.0094	0.0187	0.0176	0.0122
SampG.m Q2	0.0016	0.0037	0.0067	0.0082	0.0027	0.0029	0.0027	0.0025	0.0058	0.0060	0.0057	0.0047	0.0046	0.0045	0.0037	0.0032
SampG.m Q3	0.0021	0.0046	0.0081	0.0097	0.0030	0.0033	0.0031	0.0027	0.0055	0.0060	0.0057	0.0048	0.0048	0.0046	0.0039	0.0032
SampS.m Q2	0.0017	0.0037	0.0068	0.0083	0.0028	0.0031	0.0030	0.0027	0.0062	0.0063	0.0060	0.0050	0.0051	0.0048	0.0042	0.0033
SampS.m Q3	0.0025	0.0053	0.0091	0.0109	0.0045	0.0053	0.0049	0.0044	0.0059	0.0098	0.0097	0.0087	0.0065	0.0063	0.0056	0.0037

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ISSN: 1471-2105

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