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Table 1 Diabetes-related genes. Genes with multivariate expression patterns discovered by the RIT algorithm for the diabetes data.

From: Detecting multivariate differentially expressed genes

Gene

Status

Function

Ref. (PMID)

Bcat1

D

Candidate gene for the type I diabetes susceptibility locus Idd6.

14563018

Clca2

N

Chloride channel. Multiple functions, colocalizes with adhesion molecule integrin β4.

15707651

Clcn1

N

Chloride channel. Regulates electric excitability of the skeletal muscle membrane.

7735894

Cltb

D

Involved in insulin receptor internalization.

7821727

Dopey1

N

Involved in Golgi/ER vesicle traffic.

1630131

Epha7

N

Ephrin receptor subfamily. Ephrin receptors are associated with the pancreatic islets.

15681844

Hcap-G

N

Chromosome condensation protein, member of the condensin complex.

14593730

Kcng1

D

Potassium channel. Potassium channels are involved in regulation of insulin secretion.

16567526

Loc51152

N

Melanoma antigen.

 

Psmal

D

Glutamate carboxypeptidase. Inhibition prevents long-term type 1-diabetic neuropathy.

11809162

Sox5P

N, T

Transcription factor activity (GeneOntology). Related to the sex determining region Y-gene.

 

Sptlc2

N

Sphingolipid biosynthesis enzyme, upregulated upon transepidermal water loss.

12445191

Ssx2

N, T

Suggested role as transcriptional repressor.

12007189

Tfap2B

D, T

Genetic variations in this gene are associated with type 2 diabetes.

15940393

Usp9Y

N

Associated with male infertility and Sertoli cell-only (SCO) syndrome.

12871878

Zf

N, T

Specific inhibitor of the transcription factor Luman. Inhibits herpes virus replication.

16282471

  1. Status column: D, diabetes-related; N, novel; T, transcription factor.