Table 2 Extracted switches in the network. Significantly differentially expressed pairs of reactions (p-value ≤ 0.01). The first 20 switches are shown here and described in detail in the text.
Rank | Up-regulated reactions | Metabolites | Down-regulated reactions | P-value |
|---|---|---|---|---|
1 | formate hydrogenlyase complex | formate | formyltetrahydrofolate deformylase | 4.67E-14 |
2 | acetaldehyde dehydrogenase | acetaldehyde | ethanolamine ammonia-lyase | 1.25E-12 |
3 | FocA formate FNT transporter | formate | formyltetrahydrofolate deformylase | 5.81E-12 |
4 | formate hydrogenlyase complex | formate | GTP cyclohydrolase I | 1.65E-11 |
5 | 3-methyl-2-oxobutanoate hydroxymethyltransferase | 2-dehydropantoate | 2-dehydropantoate reductase | 2.33E-11 |
6 | serine hydroxymethyltransferase | tetrahydrofolate, 5,10-methylene-THF, glycine | gcv system | 6.69E-09 |
7 | serine hydroxymethyltransferase | glycine | glycine dehydrogenase (decarboxylating) | 2.07E-08 |
8 | formate dehydrogenase | formate | formyltetrahydrofolate deformylase | 1.30E-07 |
9 | 2-keto-4-hydroxyglutarate aldolase | glyoxylate | glyoxylate reductase B,glyoxylate reductase | 1.74E-07 |
10 | fumarate reductase | fumarate | 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase | 2.00E-07 |
11 | fumarate reductase | fumarate | adenylosuccinate lyase | 2.00E-07 |
12 | CTP synthetase | UTP | galactose-1-phosphate uridylyltransferase | 3.16E-07 |
13 | gluconokinase | gluconate | 2-ketoaldonate reductase | 1.36E-05 |
14 | phosphoenolpyruvate carboxylase | oxaloacetate | aspartate transaminase | 2.00E-05 |
15 | FocA formate FNT transporter | formate | GTP cyclohydrolase I | 3.35E-05 |
16 | BrnQ branched chain amino acid LIVCS transporters | L-isoleucine | branched chain amino acids ABC transporters | 3.78E-05 |
17 | BrnQ branched chain amino acid LIVCS transporters | L-leucine | branched chain amino acids ABC transporters | 3.78E-05 |
18 | BrnQ branched chain amino acid LIVCS transporters | L-valine | branched chain amino acids ABC transporters | 3.78E-05 |
19 | 3-hydroxy acid dehydrogenase | L-serine | phosphoserine phosphatase | 4.33E-05 |
20 | phosphatidylglycerophosphate synthase | a CDP-diacylglycerol, CMP | CDP-diacylglycerol pyrophosphatase | 4.78E-05 |