Table 1 Extracted network clusters.

1 ^st cluster

2 ^nd cluster

argininosuccinate lyase, aspartate ammonia-lyase, dimethyl sulfoxide reductase, 3,4-dihydroxy-2-butanone 4-phosphate synthase, formate hydrogenlyase complex, formate dehydrogenase pyruvate formate-lyase, fumarate reductase, FocA formate FNT transporter

pyruvate formate-lyase activating enzyme, coproporphyrinogen III oxidase, anaerobic, anaerobic nucleoside-triphosphate reductase activating system, PFL-deactivase, ribonucleoside triphosphate reductase activase, lipoate synthase

1 ^st cluster

2 ^nd cluster

1-phosphofructokinase, 6-phosphofructokinase, 6-phospho-β-glucosidase, glucokinase, mannitol-1-phosphate 5-dehydrogenase, mannose-6-phosphate isomerase, phosphoglucose isomerase, EIIMan transporter

glyceraldehyde 3-phosphate dehydrogenase, 2-keto-3-deoxy-6-phosphogluconate aldolase, phosphogluconate dehydratase, phosphoglycerate kinase, triose phosphate isomerase

1 ^st cluster

2 ^nd cluster

2,3-dihydroxybenzoate-AMP ligase, 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase, serine activating enzyme, aryl carrier protein, enterobactin synthase multienzyme complex, isochorismatase, isochorismate synthase, enterochelin esterase

cysteine desulfurase, selenocysteine lyase, thiamin (thiazole moiety) biosynthesis protein, YaaJ alanine AGSS transporter, valine-pyruvate aminotransferase

aspartate-ammonia ligase, asparagine synthetase B, ATP phosphoribosyltransferase, CDP-diglyceride synthetase, CTP synthetase, imidazole glycerol phosphate synthase, histidinal dehydrogenase, histidinol-phosphate aminotransferase, phosphoribosyl-AMP cyclohydrolase, histidinol-phosphatase, histidinol dehydrogenase, phosphoribosyl-ATP pyrophosphatase, imidazoleglycerol-phosphate dehydratase, L-aspartate oxidase, phosphoribosylformimino-5-amino-1-phosphoribosyl-4-imidazole carboxamide isomerase, quinolinate synthase complex, protein-(glutamine-N5) methyltransferase, aspartate DAACS transporter

1 ^st cluster

2 ^nd cluster

dGDP kinase, nucleoside diphosphate kinase ribonucleoside-diphosphate reductase, deoxyguanylate kinase, GTP cyclohydrolase I, guanylate kinase, guanosine-3',5'-bis(diphosphate) 3'-diphosphatase, ribonucleoside-diphosphate reductase

dTDP-glucose pyrophosphorylase, dTDP kinase, UDP-glucose-hexose-1-phosphate uridylyltransferase, UDP-galactopyranose mutase, nucleoside diphosphate kinase, galactose-1-phosphate uridylyltransferase

gcv system, glycine dehydrogenase (decarboxylating), aminomethyltransferase

glutathione synthetase, glycyl-tRNA synthetase, lipoyl-protein ligase A