Figure 3From: HMM-ModE – Improved classification using profile hidden Markov models by optimising the discrimination threshold and modifying emission probabilities with negative training sequencesDetermination of optimal discrimination threshold. The average MCC(bold black) distribution is overlayed on the sensitivity and specificity plots for each of 10-fold cross validation samples of the PVPK sub-family. Figures are plotted for the default profile HMM-d (top, A), HMM-ModE (center, B) and HMM-Sub(bottom, C).Back to article page