From: Application of Petri net based analysis techniques to signal transduction pathways
ID | Transition name | Biological event |
---|---|---|
1 | MATalpha_cell(surroundings) | a near MATα cell secretes its mating pheromone |
2 | binding_factor _to_receptor | the α-factor binds to the Ste2 receptor |
3 | receptor_synthesis | synthesis of the cell surface receptor Sst2 |
4 | receptor _conformation_change | conformation change of the receptor |
5 | division(in_alpha_subunit:GDP->GTP) | dissociation of the Gα subunit of the G-protein |
6 | hydrolysis_GTP->GDP | hydrolysis reassociates Gα with Gβγ |
7 | interact_through_Far1 | Gβγ interacts Far1 transmitted with Cdc24 |
8 | Cdc42:GDP->GTP | Cdc24 supported activation of Cdc42 |
9 | active_Cdc42_constitutive_at_pm | constitutive active Cdc42 attending the processes |
10 | binding_to_Ste20 | Gβγ binds Ste20 |
11 | Ste20_activated | Cdc42 at plasma membrane activates Ste20 |
12 | binding_to_Ste5 | Gβγ binds Ste5 |
13 | Ste5_binds_Ste11 | Ste5 binds Ste11 |
14 | Fus3_synth | synthesis of kinase Fus3 |
15 | Fus3_binds_Ste7 | Ste7 binds Fus3 |
16 | complex-formation | Ste5/Ste11 binds Ste7/Fus3 |
17 | Ste20_phos_Ste11 | phosphorylation of Ste11 by Ste20 |
18 | Ste11_phos_Ste7 | phosphorylation of Ste7 by Ste11 |
19 | Ste7_phos_Fus3 | phosphorylation of Fus3 by Ste7 |
20 | Fus3PP-release | release of activated Fus3 out of the MAPK complex |
21 | binding_free_Fus3 | remaining MAPK complex binds Fus3 |
22 | Ste12_inhibit _phos | phosphorylation of Ste12 inhibitors Dig1/Dig2 by Fus3PP |
23 | Ste12-release | release of Ste12 out of the repression complex |
24 | Ste12_phos | phosphorylation of Ste12 by Fus3PP |
25 | transcr_activation | transcription activation of pheromone regulated genes |
26 | Fus3PP_dephos | dephosphorylation of Fus3PP by Msg5 |
27 | repression_through_Fus3 | Ste12 repression through inactive Fus3 and Dig1/Dig2 |
28 | cell_fusion | processes leading to the fusion of the two haploid cells |
29 | transport_out_of_cell | Bar1 transport into the cell environment |
30 | factor _destruction | Bar1 transmitted destruction of the α-factor |
31 | Far1_phos | phosphorylation of Far1 by Fus3PP |
32 | cell_cycle_arrest in_G1 | Far1 caused arrest in the cell cycle phase G1 |
33 | transport_out_of_nucleus | Far1 transport out of the nucleus |
34 | Sst2_phos | phosphorylation of Sst2 by Fus3PP |
35 | transport_out_of_nucleus | Sst2 transport out of the nucleus |
36 | accelerated_hydr_GTP->GDP | accelerated hydrolysis reassociates the G-protein |
37 | Ste11_neg_phos | Fus3PP labels the MAPK complex at Ste11 for degradation |
38 | degradation | degradation of the MAPK complex |
39 | Ste7_neg_phos | Fus3PP labels the MAPK complex at Ste7 for degradation |
40 | Ste7_phos_Kss1 | phosphorylation of Kss1 by Ste7 |
41 | accelerated-dephos_Kss1 | deactivation of phosphorylated Kss1 by Fus3PP |
42 | Kss1_dephos | dephosphorylation of phosphorylated Kss1 by Msg5 |
43 | repression_through_Kss1 | Ste12 repression through inactive Kss1 and Dig1/Dig2 |
44 | techn_input | technical: the repressed Ste12 complex assumed to be present |
45 | Akr1_synthesis | synthesis of Akr1 |
46 | Akr1_binds_Yck1/Yck2 | Akr1 binds Yck1/Yck2 |
47 | receptor_phos | labelling of Ste2 for degradation |
48 | ubiquit_endocytosis | ubiquitination and endocytosis of the receptor |