Table 3 Results for validating the simulated annealing bump hunting strategy using the mixed experimental amino acid substitutions occurring in the E. coli lac repressor and the bacteriophage T4 lysozyme.
From: Searching for interpretable rules for disease mutations: a simulated annealing bump hunting strategy
| Â | Â | Training set | Test set | ||||
|---|---|---|---|---|---|---|---|
| Â | Number of features | Box mean | Box size | Discrimination power | Box mean | Box size | Discrimination power |
Intolerant | 1 | 0.933 | 0.033 | 23.374 | 0.938 | 0.021 | 25.057 |
| Â | 2 | 0.934 | 0.020 | 23.794 | 0.917 | 0.015 | 18.383 |
| Â | 3 | 0.926 | 0.040 | 20.782 | 0.900 | 0.020 | 15.034 |
| Â | 4 | 0.953 | 0.021 | 33.947 | 0.955 | 0.015 | 35.042 |
| Â | 5 | 0.947 | 0.041 | 29.729 | 0.936 | 0.021 | 24.228 |
Tolerant | 1 | 0.917 | 0.056 | 6.588 | 0.933 | 0.120 | 8.377 |
| Â | 2 | 0.955 | 0.052 | 12.734 | 0.944 | 0.048 | 10.168 |
| Â | 3 | 0.919 | 0.054 | 6.820 | 0.947 | 0.050 | 10.633 |
| Â | 4 | 0.983 | 0.060 | 35.248 | 0.927 | 0.064 | 7.613 |
| Â | 5 | 0.961 | 0.051 | 14.673 | 0.936 | 0.052 | 8.741 |