Table 2 Sets of folds confused by both VAST and SHEBA.

1

a.28, a.39

50

29

57

51

10

16

64

4 helix bundle up-and-down (a.28), and 4 helix array of 2 hairpins folds. Confusion is caused by match of helices oriented similarly. Folds confused mostly by SHEBA.

2

a.46, a.52

9

45

97

46

7

36

20

4 helix bundle left and right-handed super helix (a.46), and 4 helix right-handed super helix folds. Confusion is caused by match of helices oriented similarly. Folds confused mostly by SHEBA.

3

a.47, a.7

24

87

88

98

8

20

40

3 helix bundle (a.7) and 4 helix bundle (a.47) folds. Confusion due to match of very similar structure. Folds confused mostly by SHEBA.

4

b.68, b.69, b.66, b.67, b.70

45

92

98

94

40

83

48

Beta-propellers (repetitive 4-stranded blades) folds, of 4, 5, 6, 7 or 8 blades depending on the fold. Confusion is caused by match of several 4-stranded blades among domains of these folds.

5

b.1, b.2, b.3, b.7, b.12.

297

19

66

29

32

68

48

Beta sandwich folds of 7, 8, 9 stranded-sheet, with Greek-key topology. The motif causing the confusion among folds is a sandwich, which is rather well matched between domains of these folds.

6

b.24, b.71

24

69

97

72

27

93

29

Sandwich fold, with 10 strands in 2 sheets, and "folded meander topology" fold (b.24), and folded sheet with Greek-key topology. Confusion is due to match of parts of the sheets of the common core of these folds.

7

b.60, b.61

30

63

90

70

57

78

74

Closed barrel, with meander topology. Confusion caused by good match of between barrel motifs of the common core.

8

b.43, b.49, b.58, b.44

39

42

71

59

32

72

44

Folds of closed barrel with Greek-key topology. Confusion is due the match of substantial part of the barrel common core, among domains of these folds.

9

b.107, b.4

4

100

100

100

25

100

25

Sandwich fold (b.4), and closed barrel fold (b.107). Confusion is caused by the good match between a deformed barrel motif and a sandwich motif.

10

b.34, b.38

62

69

67

103

19

49

39

Barrel folds, with meander topology. Confusion is caused by the match between the barrel common cores.

11

b.38, b.56

12

52

100

52

65

93

70

Open barrel (b.38) and closed barrel (b.56) folds. Confusion is caused by the match of the barrel.

12

b.10, b.19, b.13, b.18, b.22, b.23

91

42

76

55

16

54

29

Folds with common core motif of beta sandwich; the 2 sheets are made of 8, 9 or 10 strands depending on the fold, and with jelly roll topology. The confusion among these folds is caused by the match of the strands of the beta sandwich common core.

13

c.1, c.6

185

62

75

83

78

87

90

TIM barrel (c.1) and variant of beta/alpha barrel, with closed parallel beta-sheet barrel (c.6) folds. Confusion is caused by the match of almost the whole TIM barrel.

14

c.8, c.98

14

50

75

68

30

54

56

3 layer beta/beta/alpha (c.8) and 3 layer alpha/beta/alpha (c.98) folds. Confusion is caused by the match between common beta/alpha layers.

15

c.84, c.95

19

65

91

71

55

92

60

3 layer alpha/beta/alpha of 4 strands (c.84), and of 5 strands (c.95) folds. Match of the 3 layer alpha/beta/alpha common core causes the confusion.

16

c.101, c.73, c.27

7

11

100

11

49

100

49

3 layer alpha/beta/alpha folds, with 5, 6 or 8 strands depending on the fold. Confusion is caused by the match of the 3 layer alpha/beta/alpha common core.

17

c.100, c.28, c.25, c.24, c.30, c.78, c.108, c.116, c.31, c.114, c.3, c.4, c.49, c.59, c.16, c.57, c.44, c.48, c.2, c.33, c.32, c.34, c.23, c.62, c.65, c.5

334

24

80

31

51

92

56

3 layer alpha/beta/alpha folds, with beta sheet of 4, 5, 6 or 7 strands depending of the fold. 3 layer beta/beta/alpha with central of 5 strands for c.3. Confusion among 3 layer alpha/beta/alpha folds is caused by the match of the 3 layer alpha/beta/alpha common core. Confusion between 3 layer alpha/beta/alpha and beta/beta/alpha is caused by the match of the 2 layer beta/alpha.

18

d.13, d.173

7

26

93

28

43

86

50

Fold containing the 3 layer alpha/beta/alpha common core (d.130 and unusual fold containing a common core of beta-alpha-beta-alpha-beta-alpha-beta (d.173). Confusion caused by the match of some strands and helices.

19

d.65, d.67

7

47

46

102

60

64

93

2 layer alpha/beta sandwich fold. Confusion caused by the match of 2 layer alpha/beta sandwich common core.

20

d.181, d.212

5

50

60

83

17

60

28

Folds containing beta-alpha-beta units. Confusion caused by match on the alpha/beta layers.

21

d.10, d.50

14

34

66

51

40

61

66

2 layer alpha/beta folds. Confusion caused by match on the 2 layer alpha/beta common cores.

22

d.140, d.68

12

34

68

51

40

52

77

Fold with 2 layer beta/alpha sandwich common core. Confusion is caused by match of the 2 layer beta/alpha sandwich.

23

d.151, d.160

7

75

100

75

58

100

58

Beta-sandwich; duplication of alpha+beta (d.151), 4 layers: alpha/beta/beta/alpha; mixed beta sheets (d.160) folds. Confusion due to match of the alpha beta sandwich.

24

d.95, d.206, d.64

12

18

96

18

34

79

43

2 layer alpha/beta sandwich folds. Confusion caused by the match of the 2 layer alpha/beta sandwich.

25

d.11, d.40

5

100

100

100

67

100

67

2 layer alpha/beta sandwich folds. Confusion caused by match of the 2 layer alpha/beta sandwich.

26

d.130, d.80, d.52

19

53

90

59

51

62

82

2 layer alpha/beta sandwich folds. Confusion is caused by the match of the 2 layer alpha/beta sandwich.

27

d.45, d.74, d.58, d.51, d.94, d.141, d.105

160

43

58

74

48

59

81

2 layer alpha/beta sandwich, and two beta-sheets and one alpha-helix packed around single core (d.141) folds. Confusion caused by match of the sheet and strands of the 2 layer alpha/beta sandwich core motif.

28

e.24, c.16, c.57, c.44, c.23, c.5

79

47

73

64

68

85

80

A domain component of a "multi-domain" domain of fold e.24 can matches the full domain of another fold which does not belong to the E class

29

e.4, c.48, c.2, c.32, c.33, c.34, c.23

178

35

74

48

74

87

85

A domain component of a "multi-domain" domain of fold e.4 matches the full domain of another fold which does not belong to the E class