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Figure 1 | BMC Bioinformatics

Figure 1

From: Identifying metabolic enzymes with multiple types of association evidence

Figure 1

a. Illustration of the missing gene problem. Metabolic network neighborhood of a missing metabolic enzyme is shown. The neighborhood comprises layers with increasing radii (3 layers shown, indicated by shading). Majority of the enzyme-encoding genes in the neighborhood are known. b. Illustration of the self-rank validation test. Ability to predict known enzyme-encoding genes is tested by measuring its self-rank - the rank of a true enzyme-encoding gene in the candidate set. The candidates are ordered according to overall strength of their functional association with the metabolic network neighborhood of the enzyme. The overall association strength is a combination of layer association scores that measure strength of functional association of the candidate gene with known enzyme-encoding genes in a single layer of the metabolic neighborhood (3 layers, as illustrated in a.). The candidate set contains all genes that are not already part of the metabolic network.

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