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Table 2 The top 10 matches to the BRC1_HUMAN gene after searching the UniProt human proteome with a D-value cutoff of 0.05 in the Biological Process Category (data source: DAG-Edit version 1.419 Rev 3 and EBI goa_human.28)

From: Gene functional similarity search tool (GFSST)

Protein

Summary of functions

D-value

BRCA1_HUMAN

Plays a central role in DNA repair by facilitating cellular response to DNA repair

0.000000000

P53_HUMAN

Acts as a tumor suppressor in many tumor types

0.0064676759

VHL_HUMAN

Von Hippel-Lindau disease tumor suppressor

0.0094604740

P73_HUMAN

Participates in the apoptotic response to DNA damage

0.0102616186

INHA_HUMAN

Inhibin alpha chain [Precursor]

0.0119586522

INHBA_HUMAN

Inhibin beta A chain [Precursor]

0.0119586522

CGRF1_HUMAN

Cell growth regulator with RING finger domain 1

0.0120311036

MAT1_HUMAN

CDK-activating kinase assembly factor MAT1

0.0189669271

PMS1_HUMAN

Probably involved in the repair of mismatches in DNA

0.0191020767

RBBP8_HUMAN

Retinoblastoma-binding protein 8

0.0191020767

IRF1_HUMAN

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes

(the interferon consensus sequence (ICS)) and activates those genes.

0.0238448534