Table 2 The 40 first ranking reactions when applying the feature extraction directly without any network information.
Rank | reaction id (EcoCyc) | corresponding enzyme | regulation | p-value | involved in extracted sub-graph |
|---|---|---|---|---|---|
1 | TRANS-RXN-1 | transporter | 1 | 4.5e-20 | 1,2,5,6 |
2 | PYRUVFORMLY-RXN | pyruvate formate-lyase | 1 | 2.2e-18 | 1,2,5,6 |
3 | GCVT-RXN | aminomethyltransferase | -1 | 2.8e-18 | none |
4 | FHLMULTI-RXN | formate hydrogenlyase complex | 1 | 3.8e-16 | 1,2,5 |
5 | 2PGADEHYDRAT-RXN | enolase | 1 | 5.1e-15 | none |
6 | GCVP-RXN | glycine dehydrogenase (decarboxylating) | -1 | 6.3e-15 | none |
7 | 3-CH3-2-OXOBUTANOATE-OH- CH3-XFER-RXN | 3-methyl-2-oxobutanoate hydroxymethyltransferase | 1 | 7.1e-15 | none |
8 | PEPDEPHOS-RXN | pyruvate kinase I | 1 | 9.1e-15 | none |
9 | PFLDEACTIV-RXN | PFL-deactivase | 1 | 3.0e-14 | none |
10 | ACETALD-DEHYDROG-RXN | acetaldehyde dehydrogenase | 1 | 3.0e-14 | none |
11 | FORMATEDEHYDROG-RXN | formate dehydrogenase | 1 | 3.7e-14 | none |
12 | GCVMULTI-RXN | gcv system | -1 | 7.7e-14 | none |
13 | NACMURLALAAMI-RXN | N-acetylmuramyl-L-alanine amidase | 1 | 8.6e-14 | none |
14 | R601-RXN | fumarate reductase | 1 | 1.1e-13 | none |
15 | MANNONDEHYDRAT-RXN | mannonate dehydratase | -1 | 2.0e-13 | none |
16 | GLUTDEHYD-RXN | glutamate dehydrogenase (NADP+) | 1 | 2.8e-13 | none |
17 | 1.97.1.4-A-RXN | pyruvate formate-lyase activating enzyme | 1 | 4.8e-13 | none |
18 | TDCEACT1-RXN | pyruvate formate-lyase activating enzyme | 1 | 4.8e-13 | none |
19 | GLUTRNAREDUCT-RXN | glutamyl-tRNA reductase | 1 | 1.4e-12 | none |
20 | HISTAMINOTRANS-RXN | histidine-phosphate aminotransferase | 1 | 1.7e-12 | none |
21 | TRIOSEPISOMERIZATION-RXN | triose phosphate isomerase | 1 | 1.9e-12 | 9 |
22 | MANNPISOM-RXN | mannose-6-phosphate isomerase | 1 | 4.5e-12 | none |
23 | NAD-KIN-RXN | putative NAD+ kinase | 1 | 4.7e-12 | none |
24 | 6PFRUCTPHOS-RXN | 6-phosphofructokinase-1 | 1 | 4.7e-12 | none |
25 | 4OH2OXOGLUTARALDOL-RXN | 2-keto-4-hydroxyglutarate aldolase | 1 | 6.0e-12 | none |
26 | KDPGALDOL-RXN | 2-keto-3-deoxy-6-phosphogluconate aldolase | 1 | 6.0e-12 | none |
27 | OXALODECARB-RXN | oxaloacetate decarboxylase | 1 | 6.0e-12 | none |
28 | ABC-26-RXN | tranport | -1 | 8.2e-12 | none |
29 | RXN0-2181 | asparaginase III | -1 | 1.4e-11 | none |
30 | RXN0-1682 | asparaginase III | -1 | 1.4e-11 | none |
31 | RXN0-307 | NADH oxidoreductase | 1 | 1.8e-11 | none |
32 | RXN0-1565 | tRNA (Gm18) 2'-O-methyltransferase | -1 | 2.5e-11 | none |
33 | TRANS-RXN-242A | Transporter | 1 | 3.0e-11 | none |
34 | PHOSICITDEHASE-RXN | isocitrate dehydrogenase kinase | -1 | 3.1e-11 | none |
35 | DEPHOSICITDEHASE-RXN | isocitrate dehydrogenase phosphatase | -1 | 3.1e-11 | none |