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Table 1 Almost all globally essential reactions in E. coli, S. cerevisiae and S. aureus are UP or UC. The p value represents the probability that the indicated overlap would arise in a null model as discussed in the text.

From: Low degree metabolites explain essential reactions and enhance modularity in biological networks

Organism

E. coli

S. cerevisiae

S. aureus

Total number of reactions

1176

1579

865

Number of globally essential reactions

164

127

196

Number of globally essential reactions that are UP or UC in the entire network

133 (p < 10-37)

86 (p < 10-12)

157 (p < 10-32)

Number of globally essential reactions that are UP or UC in the reduced network

156 (p < 10-62)

117 (p < 10-41)

182 (p < 10-58)