Metabolite coupling in genome-scale metabolic networks

Table 2 Coupling of prominent metabolites. The number of metabolites that couple with each compound. In the E. coli metabolic network, the proton participates in at least one reaction with 479 other unique metabolites. The ordering of metabolites is based on the number of reactions they participate in individually, averaged across all networks. Thus, the number of unique metabolites that couple with a given metabolite do not strictly have to decrease down a column, although it usually does.

	Number of unique metabolites with which each prominent metabolite couples
Metabolite	E. coli	S. cerevisiae	H. pylori	S. aureus	mitochondrion	M. barkeri
H⁺	479	490	291	400	97	402
H₂O	368	361	214	275	65	265
ATP	220	262	135	214	59	215
ADP	179	161	114	142	42	134
P_i	184	161	123	132	34	165
PP_i	140	175	101	143	28	166
CO₂	116	125	90	122	33	104
NAD⁺	126	121	44	108	34	86
NADP⁺	92	144	71	97	14	86
NADH	123	116	37	111	34	78
CoA	72	109	46	95	49	59
NADPH	90	143	68	105	14	83
AMP	72	126	39	80	24	108
glu	84	80	57	71	17	91
NH₄	80	88	58	68	14	64