Figure 4

Enrichment of the interface definitions by peptidic-ligands and solvent. A) Enrichment in the description of protein interfaces by peptidic-ligands. The molecular recognition features of the BTB/POZ domain family are summarized. A representative POZ domain (green) is surrounded by five different ligands representing all possible BTB/POZ binding zones. Peptidic-ligands are represented in grey (PDB codes and chains used: 11dk_A, 11qb_ACD, 1r2b_D). B) Enrichment in the description of protein interfaces by wet spots. The complex of TEM1 β-lactamase (orange surface) with the inhibitor BLIPII (green ribbon; PDB 1jtd) is shown. White represents residues forming the interface before taking into account wet spots (in blue). C) The α and β (orange and green ribbon, respectively) chains of the Respiratory nitrate-reductase 1 (PDB 1q16) are shown. White represents residues forming the interface before taking into account wet spots (in blue). Figures created with InsightII, Accelrys.