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Table 2 Pathway significance. Pathways in the van 't Veer et al. [15] data set, ordered by significance and their number of transcription factors (TF) and downstream targets (DT). Also shown are Group Correlation Score (GCS) and Exclusive Group Correlation Score (EGCS) p-values. ER means both induced and repressed ER-pathway and (v) means that the pathway has been verified in a second experiment (see [14]).

From: Signal transduction pathway profiling of individual tumor samples

Pathway

# of TF

# of DT

GCS p-value

EGCS p-value

IL-1

5

21

1e-04

4e-01

fMLP

9

27

4e-04

1e-01

TLR4

9

41

9e-04

1e-03

EDAR

6

41

3e-03

5e-02

ER-induced

1

50

3e-03

n/a

RANK

6

41

3e-03

5e-02

Oncostatin M

1

2

5e-03

n/a

PDGF

8

15

6e-03

2e-02

ER

1

77

7e-03

n/a

ER-induced(v)

1

5

7e-03

n/a

IL-4 – STAT6

1

6

8e-03

n/a

TGF-β network

7

23

1e-02

1e-02

EGF

12

53

1e-02

1e-02

ER (v)

1

7

2e-02

n/a

Insulin

7

45

2e-02

4e-02

VEGF

3

8

2e-02

2e-02

TNF-α

8

61

2e-02

5e-02

TPO

6

10

3e-02

2e-02

PRL

6

10

3e-02

2e-02

IFN

6

10

3e-02

2e-02

IL-10

2

7

5e-02

5e-02

IL-12 – STAT4

1

3

7e-02

n/a

c-Kit

4

87

8e-02

6e-02

ER-repressed

1

27

1e-01

n/a

B-cell antigen receptor

4

10

3e-01

3e-01

T-cell antigen receptor

4

10

3e-01

3e-01

Wnt pathway

2

8

4e-01

3e-01

ER-repressed (v)

1

2

6e-01

n/a

IL-2 – STAT5

2

4

8e-01

7e-01