Figure 2

ER-induced pathway heatmap. Heatmap of the ER-induced pathway activity corresponding to Table 4. The vertical divisions correspond to samples where the ER-induced pathway is significantly upregulated (30 samples, red bar), its status undetermined (50 samples, black bar) or significantly downregulated (37 samples, green bar) respectively. The rows represent genes in the ER-induced pathway. The genes are shown in descending order according to scalar product with the vector ± (1 - p-value) for each sample, where the sign is the sign of the pathway activity of that sample. The expression values are log ratios normalized as described in Methods. Red and green represent up- and down-regulation respectively, and the precise color scheme is illustrated in the color key.