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Table 1 Category p-values for cutoff-based and cutoff independent score functions. The 15 GO categories with the lowest Wilcoxon rank sum p-values from the ranked gene list, based on the data set of van't Veer et al., which comprises 5224 genes in total. Three columns show p-values for cutoff based score functions, with cutoffs at position 100, 300 and 600 in the list. The columns "min p" and "cutoff" give the minimal cutoff based p-value and the cutoff where this minimum was attained. The column "WRS" gives the p-value calculated with the Wilcoxon rank sum as score function and random permutation of genes as null hypothesis, and the column marked #genes indicates the total number of genes in the category. A full table (sorted by WRS p-value) is given as supplementary information [see Additional file 2]. The supplementary table also contains the ranking of each category using the different methods and the 25th, 50th and 75th percentiles of those genes in the ranked list.

From: Comparing functional annotation analyses with Catmap

GoName

GoId

top100

top300

top600

min p

cutoff

WRS p

#genes

mitotic cell cycle

0000278

9e-05

5e-10

6e-07

3e-10

290

7e-08

93

M phase

0000279

1e-03

2e-06

1e-04

1e-09

1491

1e-07

41

nuclear division

0000280

1e-03

2e-06

1e-04

4e-09

1491

2e-07

40

M phase of mitotic cell cyc..

0000087

6e-04

5e-07

1e-04

2e-08

1491

5e-07

36

mitosis

0007067

5e-04

4e-07

1e-04

6e-08

1491

1e-06

35

cell cycle

0007049

2e-04

3e-07

1e-05

1e-07

1571

6e-06

172

carbon-nitrogen ligase act..

0016884

4e-04

3e-03

1e-02

3e-05

27

2e-05

2

carboxylic acid metabolism

0019752

9e-02

1e-04

4e-05

3e-06

711

3e-05

83

organic acid metabolism

0006082

9e-02

1e-04

4e-05

3e-06

711

3e-05

83

intramolecular isomerase ..

0016863

1e+00

3e-02

8e-04

2e-05

609

5e-05

4

cell proliferation

0008283

7e-04

2e-05

1e-03

4e-06

1956

8e-05

264

intramolecular isomerase ..

0016860

1e+00

2e-02

3e-03

3e-05

905

1e-04

9

spindle microtubule

0005876

4e-04

3e-03

1e-02

6e-05

42

1e-04

2

DNA replication and chro..

0000067

6e-02

3e-04

2e-03

9e-05

852

3e-04

44

regulation of mitosis

0007088

9e-03

8e-03

5e-02

3e-04

1248

5e-04

8