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Table 1 Kelch-repeat proteins of H. sapiens

From: Molecular phylogeny of the kelch-repeat superfamily reveals an expansion of BTB/kelch proteins in animals

Architecture

Domain organisation

GenBank Accession

Alternate name

Amino Acids

Chromosome localisation

Reference

BTB/kelch

      
 

BTB/K5(C)

NP_055666

KIAA0469

539

1p36.23

75

 

BTB/K5(C)

NP_006054

Sarcosin, KLP23, Krp1

606 +

2q31.1

76, 77

 

BTB/K5(C)

AAH10437

 

558

2q31.1

78

 

BTB/K5(C)

NP_115894

Tcell activation kelch-repeat protein

575

3p14

79

 

BTB/K5(C)

NP_689606

Sarcosynapsin

472

3p21.32

 
 

BTB/K5(C)

NP_060114

 

412

3q27.3

 
 

BTB/K5(C)

XP_291224

KIAA1489

623

7p14.3

 
 

BTB/K5(C)

XP_063481 *

 

819

14q11.1

 
 

BTB/K5(C)

XP_171687 *

 

458 $

15q21.2

 
 

BTB/K6(C)

NP_005888

IPP

584

1p32

80

 

BTB/K6(C)

NP_055273

Kelch motif-containing protein, KLX

609

1q24.1-24.3

 
 

BTB/K6(C)

NP_006460

NS1-binding protein, Nd1 orthologue

642

1q25.1

81, 82

 

BTB/K6(C)

NP_067646

Kelch-like protein C3IP1

568

1q31.3

 
 

BTB/K6(C)

BAB67814

KIAA1921

545

2p23.2

83

 

BTB/K6(C)

XP_292990

 

649

2q37.3

 
 

BTB/K6(C)

XP_093813 *

 

585

3q21.3

 
 

BTB/K6(C)

BAB93503

 

509

3p21.31

 
 

BTB/K6(C)

NP_569713

KLHL6

610

3q27.3

84, 85

 

BTB/K6(C)

NP_057074

KLHL5, lymphocyte activation-associated protein

734 @

4p15.1

86

 

BTB/K6(C)

NP_009177

Mayven, KLP2

593

4q21.2

87

 

BTB/K6(C)

NP_065854

KLHL8

620

4q21.3

88

 

BTB/K6(C)

NP_003624

ENC-1, Nrp/b

589

5q12-q13.3

89, 90

 

BTB/K6(C)

NP_059111

KLHL3

587

5q31

91, 92

 

BTB/K6(C)

CAC16284

 

634

6p12.1

 
 

BTB/K6(C)

NP_443136

KIAA1900

620

6q16.3

93

 

BTB/K6(C)

NP_061334

 

564

7q15.3

 
 

BTB/K6(C)

NP_055682

KIAA0711

623

8p23.2

94

 

BTB/K6(?)

XP_294387 *

 

649

8q24.13

 
 

BTB/K6(C)

NP_005884

Calicin

588

9p11.2

95

 

BTB/K6(C)

NP_061335

KIAA1354

617

9p22

88

 

BTB/K6(C)

NP_060565

 

518

11p11.12

 
 

BTB/K6(C)

AAH42952

 

431(a)

11q13.3

 
 

BTB/K6(C)

NP_689646

 

608

11q22.3

 
 

BTB/K6(C)

XP_044836

 

505

12q11.23

 
 

BTB/K6(C)

NP_115514

 

684

13q13.3

96

 

BTB/K6(C)

NP_065917

KLHL1

748

13q21

97

 

BTB/K6(C)

XP_058629 *

 

309(b)

14q21.1

 
 

BTB/K6(C)

NP_071925

 

589

15q25.2

 
 

BTB/K6(C)

NP_079007

 

616

16q23.3

 
 

BTB/K6(C)

NP_071324

gigaxonin

597

16q24.1

98

 

BTB/K6(C)

NP_689680

KLHL10

614

17q21.2

 
 

BTB/K6(C)

NP_060613

 

708

17q21.2

 
 

BTB/K6(C)

spQ9P2G3 *

KIAA1384

628

18q12.1

88

 

BTB/K6(C)

NP_060786

 

615

19p13.11

 
 

BTB/K6(C)

NP_036421

Keap1

624

19p13.2

98, 99

 

BTB/K6(C)

NP_116164

 

634

22q11.21

 
 

BTB/K6(C)

NP_695002

 

644

Xp22.13

 
 

BTB/K6(C)

NP_476503

KLHL4

720

Xq21.3

100

 

BTB/K6(C)

XP_040383

KIAA1677

604

Xq22.1-q21

 
 

BTB/K6(C)

spQ9P2N7

KIAA1309

639

Xq23-q24

 
 

K6/BTBx2(N)

NP_006758

LZTR-1 ^

552

22q11.21

69

Discoidin/kelch

      
 

DD/K6(N)

NP_037387 *

muskelin

735

7q32

71

F-box/kelch

      
 

F-box/K5(N)

XP_048774

KIAA1332

717

1p36.13

 

LCM/kelch

      
 

LCM/K6(?)

NP_055608 *

p21Waf/CIPpromoter-binding protein

686

15q14

26

Kelch and PHD

      
 

K6/u/PHD(N)

NP_000527 *

RAG-2

527

11p13

16

Kelch and multidomain

      
 

K6/HCF/FNIII

NP_005325

Host cell factor-1(N)

1938

Xq28

30

 

CUB/DSL/K4?

CAC12966

 

510

10q26.11

 
 

K5/CL(C)

BAA25460

KIAA0543

1011

10q26

101

 

K6/FNIII(N)

NP_037452

Host cell factor-2

792

12q23.3

31

 

CUB/K6/E(N)

PIRT00209

MEGF8, pregnancy-specific β 1 glycoprotein

1737 +

19q12

102

 

CB/K6/CL(N)

NP_647537 *

Attractin, mahogany

1198, 1429 +

20p13

27–29

Kelch and unique

      
 

u/K6(C)

NP_689588

 

559

1p36.13

 
 

K6/u(N,?)

NP_060036

 

520

16q24.3

 
 

u/K5(C)

NP_612442

 

495

22q13.33

 

Propeller only

      
 

K7(N)

NP_060673

 

350

1q32.1

 
 

K7(N)

NP_775817 *

 

354

3p21.21

 
 

K6(N,?)

NP_476502

PEAS, TIM

382

6p21.1

103

 

K6(C)

XP_045954

KIAA0265

442

7q32.2

 
 

K6(N)

NP_005824

p40 Rab9 effector

372

9q34.21

32

 

K6(C)

NP_055130

HCLP-1, Kelch domain-containing 2

406

14q21.3

104

 

K6(?)

NP_751943

Kelch domain-containing 1

406

14q21.3

 
  1. Key. + Splice variants reported. $ No EST match. @spQ96PQ7 encodes a longer protein of 755 amino acids. ^Human LZTR-1 sequence lacks amino-terminus included in mouse NP_080084. (a), human sequence not full-length, mouse orthologue (BAB28596, >90% identity, 574aa) contains a BTB domain (b), human sequence not full-length, mouse orthologue (NP_079983, >90% identity, 571aa) contains a BTB domain. *Kelch-repeat proteins not listed in either Pfam or SMART species trees. Additional domains listed include C-type lectin (CL); C1r, C1s, uEGF, and bone morphogenetic protein domain (CUB or CB); delta serrate ligand (DSL); epidermal growth factor (EGF); fibronectin type III repeats (FNIII); HCF repeats (HCF).
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