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Figure 1 | BMC Bioinformatics

Figure 1

From: Quantifying robustness of biochemical network models

Figure 1

Laub and Loomis model. In their model of the aggregation network, pulses of cAMP are produced when adenlylate cyclase (ACA) is activated after the binding of extracellular cAMP to the surface receptor CAR1. When cAMP accumulates internally, it activates the protein kinase PKA. Ligand-bound CAR1 also activates the MAP kinase ERK2. ERK2 is then inactivated by PKA and no longer inhibits the cAMP phosphodiesterase REG A. A protein phosphatase activates REG A such that REG A can hydrolyse internal cAMP. When REG A hydrolyses the internal cAMP, PKA activity is inhibited by its regulatory subunit, and the activities of both ACA and ERK2 go up. Secreted cAMP diffuses between cells before being degraded by the secreted phosphodiesterase PDE.

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