Table 3 Summary of one-sided Wilcoxon tests' P-values comparing the disease/target fraction in the target/disease neighbor with those of the randomized nodes at first-degree, second-degree, and third degree
From: A comparative study of disease genes and drug targets in the human protein interactome
Degree | First-degree | Second-degree | Third-degree |
|---|---|---|---|
Disease neighborhood | Â | Â | |
Cancer | 2.37 × 10-6 | 7.68 × 10-15 | 2.94 × 10-9 |
Cardiovascular | 4.67 × 10-4 | 1.56 × 10-41 | 2.33 × 10-54 |
Immune | 0.04 | 1.28 × 10-4 | 8.12 × 10-5 |
Metabolic | 0.72 | 0.08 | 0.99 |
Nervous | 0.70 | 0.46 | 0.92 |
Target neighborhood | Â | Â | |
Cancer | 2.82 × 10-14 | 4.67 × 10-20 | 4.76 × 10-11 |
Cardiovascular | 0.01 | 2.24 × 10-43 | 3.62 × 10-70 |
Immune | 1.48 × 10-13 | 1.13 × 10-7 | 0.01 |
Metabolic | 5.00 × 10-5 | 0.08 | 0.60 |
Nervous | 0.84 | 0.71 | 0.35 |