Method | Target | Depth | Purity | Sensitivity | FDR |
---|
This study | Misc | ×40 | 20% | 90% | <1% |
 |  | ×20 | 20% | 74% | <1% |
PRISM[15] | D | ×20 | 100% | 80% | 5% |
LUMPY[17] | D | ×40 | 20% | 96% | 4% |
 |  | ×20 | 20% | 77% | 4% |
CREST[16] | D,T | ×40 | 50% | 73-78% | 3% |
- Targeted types of rearrangement and features of simulated WGS data (including the sequencing depth) differ from tool to tool. D: deletions, T: tandem duplications, Misc: insertions, deletions, inversions, tandem duplications, and intra-chromosomal and inter-chromosomal translocations, FDR: false-detection rate.