Figure 4

Clonal evolutionary structures of tumor sample SU070. (A) Ground truth from Jan et al.[17]. (B) PhyloSub’s output summarized using a partial order plot. For clarity, we removed edges with probability less than 0.1 before laying out the nodes and we only show SNVs for which single-cell data is available. However, all the SNVs whose frequencies were reported in this study were used in the inference and (Additional file 2: Figure S1) shows the full partial order plot. The color of the border of the SNVs represents the subclonal lineage cluster that the SNV is placed into by a graph-based clustering algorithm that takes as input the co-clustering frequencies from the MCMC samples (see Section “Methods”). Note that unlike the thickness of the edges, this is simply a visualization aid, and does not fully represent the model’s posterior uncertainty in the SNV clusterings.