Figure 1
From: Identification of putative pathogenic SNPs implied in schizophrenia-associated miRNAs
miRNA biogenesis. MiRNAs are processed from hairpin-containing primary transcripts (pri-miRNAs). Pri-miRNA is cleaved firstly by Drosha to produce precursor miRNA (pre-miRNA), and then by Dicer to yield an imperfect miRNA:miRNA* duplex (mature miRNA duplex) about 22 nucleotides in length [20]. Although either strand of the duplex may potentially act as a functional miRNA, only the one strand which is incorporated into the RNA-induced silencing complex (RISC) is termed as mature miRNA.