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Figure 2 | BMC Bioinformatics

Figure 2

From: Detecting overlapping protein complexes based on a generative model with functional and topological properties

Figure 2

A graphical representation of the connection between the variables we use and the biology terms. Circle nodes represent proteins; triangle nodes represent complexes; hexagon nodes represent functions. We first introduce a model that generates protein-protein interaction A ij and protein-function association F ic based on model parameters θ ik and ψ kc . For an observed PPI network and functional profile, we estimate the values of θ ik and ψ kc . Finally, we predict protein complexes using the estimator of θ ik .

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BMC Bioinformatics

ISSN: 1471-2105

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