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Table 4 The top-20 ranked pain candidate genes gathered by our method

From: A novel method for gathering and prioritizing disease candidate genes based on construction of a set of disease-related MeSH® terms

Score

Gene

Description

140.92

Trpv1

Transient receptor potential cation channel, subfamily V, member 1

81.89

Oprm1

Opioid receptor, mu 1

55.04

Trpa1

Transient receptor potential cation channel, subfamily A, member 1

39.56

Tacr1

Tachykinin receptor 1

38.78

Comt

Catechol-O-methyltransferase

31.04

P2rx3

Purinergic receptor P2X, ligand-gated ion channel, 3

30.96

Bdnf

Brain-derived neurotrophic factor

27.58

Scn9a

Sodium channel, voltage-gated, type IX, alpha

27.48

Ptgs2

Prostaglandin-endoperoxide synthase 2

26.33

Cnr1

Cannabinoid receptor 1 (brain)

23.67

Ngf

Nerve growth factor (beta polypeptide)

23.49

Tnf

Tumor necrosis factor

23.3

Asic3

Acid-sensing (proton-gated) ion channel 3

23.09

Scn10a

Sodium channel, voltage-gated, type X, alpha subunit

22.97

Tac1

Tachykinin, precursor 1

20.58

Fos

FBJ osteosarcoma oncogene

19.83

Gal

Galanin/GMAP prepropeptide

19.72

Calca

Calcitonin-related polypeptide alpha

19.41

Il6

Interleukin 6

19.06

Grin1

Glutamate receptor, ionotropic, N-methyl D-aspartate 1