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Table 4 Candidate CNA drivers within each subtype.

From: A gene signature based method for identifying subtypes and subtype-specific drivers in cancer with an application to medulloblastoma

Subtypes

Significant candidate drivers

Subtype A

 

(WNT)

NRN1, SOX4, NUP153, FAM8A1, C6orf62, MRS2, BTN2A1, ZNF193, ZNF187, BAT3, C6orf134, ZNF318, UBR2, KIAA0240, CDC5L, MUT, ICK, FBXO9, PTP4A1, SMAP1, SLC35A1, RNGTT, SNAP91, MAP3K7 , IBTK, SFRS18, ZNF292, PHIP, DOPEY1, SYNCRIP, CASP8AP2, MARCKS, HDAC2, ASF1A, FOXO3, HSF2, CDC2L6, TSPYL4, MED23, TRMT11, FAM184A, CCDC28A, HECA, AHI1, RBM16, TULP4 , TCP1, TBP

Subtype B

 

(SHH)

PTCH1 , SLC35D2, ANGPTL2, TRPM3, UGCG, ALAD, HDHD3, STOM, ASTN2, RABGAP1, GOLGA1, AK1, SPTAN1, DNM1, BAT2L, NPLOC4

Subtype C

 

(NWS)

PDGFA, SRI, PCOLCE, EPHB4, TRIP6, SYPL1, MDFIC, MAP2K6, GPRC5C, NAV2, AHNAK, GNG3, GPR56, MAF, PMP22, IQCE, CHN2, POM121, GTF2IRD1, PCLO, FZD1 , AKAP9, PSMD11, NLK , RHOT1, ACLY, MPP3, CBX1, MMD, HEATR6, MED13, KCNJ2, TEX2, PPP3CB , DLG5, CHD3