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Table 1 List of successful targets in helminths and corresponding drug class known to be active against those target.

From: In silico approach to screen compounds active against parasitic nematodes of major socio-economic importance

S.No

Target

Biochemical class

BLAST score

Drug family

1.

Nicotinic acetylcholine receptor beta 1

Ion transport

E: 7e-27

62% identity with human NAch receptor beta 2

Cholinergic Agents

2.

Glutamate-gated chloride channel

Ion transport

E: e-137

54% similarity with human glutamate receptor

Macrolides

3.

Glutathione S-transferase

Transferases transferring alkyl or aryl groups

E: 6e-47

61% identity with human Mu isoform

Isoquinolines

4.

Tubulin beta

−

E: 0

96% similarity to human tubulin beta

Benzimidazoles

5.

Gamma-aminobutyric acid receptor

Chloride channel

−

Piperazines