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Figure 5 | BMC Bioinformatics

Figure 5

From: Near-membrane ensemble elongation in the proline-rich LRP6 intracellular domain may explain the mysterious initiation of the Wnt signaling pathway

Figure 5

Illustration of the spatial constraints. A. Ten aligned conformers of LRP6 intracellular domain which are not filtered by any spatial constraints. They are free to explore a spherical shaped conformational space. B. Constraint 1: Horizontal Plane Ten aligned conformers of LRP6 intracellular domain which pass the horizontal spatial constraint, i.e. membrane plane. They can explore a hemispherical conformational space. Signal peptide and extracellular domain are deleted. The transmembrane region (23 residues) is constrained as an α-helix. C. Constraint 2: Vertical Plane Ten aligned conformers of LRP6 intracellular domain which pass both horizontal and vertical spatial constraints. They are free to explore a smaller transected hemispherical shaped conformational space. The vertical constraint is imposed by the Wnt-FZD-DVL-AXIN-GSK3 assembly. δ is the distance between the vertical plane and transmembrane helix.

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BMC Bioinformatics

ISSN: 1471-2105

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