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Figure 1 | BMC Bioinformatics

Figure 1

From: The choice of null distributions for detecting gene-gene interactions in genome-wide association studies

Figure 1

A toy example illustrating the effect of the inappropriate choice of null distributions. Null distribution 1 follows the and null distribution 2 follows the . The observed χ2 value is 10, and the P-values are 0.0404 and 0.2650 for these two null distributions, respectively. Suppose P = 0.05 is the threshold of hypothesis testing. Then P = 0.0404 indicates a significant result, while P = 0.2650 does not. If the true null distribution is , then the use of will give many false positive results.

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