Table 4 Additional P. falciparum dPUC predictions lead to refined protein annotations
From: Using context to improve protein domain identification
Protein ID | Standard Pfam domains | Additional dPUC domains | Suggested reannotation (this study) |
|---|---|---|---|
PFE1240w | Radical_SAM, Wyosine_form | Flavodoxin_1 | Wybutosine synthesis protein (TYW1 ortholog), putative |
PFF1490w | THF_DHG_CYH_C | THF_DHG_CYH | Tetrahydrofolate dehydrogenase/cyclohydrolase (MTD1 ortholog, MIS1/ADE3 homolog without FTHFS domain), putative |
MAL8P1.139 | DDA1* | WD40 | Regulator of (H+)-ATPase in Vacuolar membrane (RAV1 ortholog), putative |
PF08_0124 | CactinC_cactus | Cactin_mid | CACTIN homolog, putative |
PF10_0152 | NTP_transf_2, PAP_assoc | Non-canonical cytoplasmic specific poly(A) RNA polymerase protein (CID13 ortholog), putative | |
MAL13P1.170 | NTP_transf_2 | PAP_assoc | Non-canonical poly(A) RNA polymerase protein (PAP2/TRF5 ortholog), putative |
PFI1560c | DUF21 | CBS, cNMP_binding | Required for mitochondrial morphology (MAM3 ortholog), putative |
PF10_0126 | WD40 | Phosphoinositide binding protein (HSV2/ATG18 ortholog), putative | |
PFI0510c | BRCT | IMS | DNA repair protein (REV1 ortholog), putative |
MAL13P1.54 | WD40 | LisH | Alternative splicing regulator (SMU-1 ortholog), putative |
PF14_0052 | cobW | CobW_C | COBW domain-containing protein 1 (CBWD1 ortholog), putative |
PF08_0012 | SET, Pre-SET | YDG_SRA | Histone lysine N-methyltransferase, putative |
PFE1445c | FG-GAP | T-cell immunomodulatory protein (human TIP homolog), putative | |
PFL0975w | IQ | RCC1 | Unconventional myosin fused to IQ and RCC1 domains, putative |
PF11_0276 | Abhydro_lipase | Abhydrolase_1 | Steryl ester hydrolase (TGL1/YEH1/YEH2 ortholog), putative |
PF13_0190 | Aha1_N | TPR_2, TPR_1 | Chaperone binding protein, putative |
PF11_0287 | CRAL_TRIO | CRAL_TRIO_N | CRAL/TRIO protein, putative |
PF11_0197 | Ank | ACBP | Acyl-CoA-binding protein, putative |
PF14_0647 | TLD | TBC | Rab GTPase activator, putative |
PFL0575w | Amino_oxidase, Thi4* | PHD | PHD finger and flavin containing amine oxidoreductase, putative |
MAL13P1.246 | E1-E2_ATPase | Cation_ATPase_C | E1-E2 ATPase, putative |
PF11_0116 | Nol1_Nop2_Fmu | Nol1/Nop2/Fmu-like protein, putative | |
MAL7P1.127 | Pkinase | Rab GTPase activator and protein kinase, putative | |
PFC0425w | zf-C3HC4, PHD | PHD finger protein, putative | |
PFI0975c | RCC1 | Regulator of chromosome condensation, putative | |
PFD0900w | RCC1 | Regulator of chromosome condensation, putative | |
MAL7P1.132 | Pkinase | Protein kinase, putative | |
PFF0810c | Ras | Ras GTPase, putative | |
PFL1990c | zf-CCHC, RRM_1 | RNA binding protein, putative | |
PF07_0066 | RRM_1 | RNA binding protein, putative | |
PF13_0147 | RRM_1 | RNA binding protein, putative | |
PFF1120c | EGF | EGF-like membrane protein, putative | |
PF14_0262 | WD40 | TPR_1 | WD40 and TPR repeats protein, putative |
PFI0275w | WD40 | WD40 repeat and EF hand protein, putative | |
PF10_0285 | WD40 | WD40 repeat protein, putative | |
PF11_0195 | WD40 | WD40 repeat protein, putative | |
PF14_0640 | WD40 | WD40 repeat protein, putative | |
MAL13P1.308 | Arm | ARM repeat protein, putative |