Skip to main content
Figure 3 | BMC Bioinformatics

Figure 3

From: Using context to improve protein domain identification

Figure 3

dPUC predicts more domains over a range of Ortholog Coherence scores on Plasmodium species. A. Illustration of scores. Domain predictions are made on hypothetical aligned orthologs and in-paralogs (Pf1, Pf2, Pv1, and Pc1). Color denotes domain family. Domain S overlaps T of the same family, so their scores are 1/3 (since they lack predictions in Pv1 and Pc1). In contrast, U is predicted 100% in its orthologs and in-paralogs. Y overlaps V but is not of the same family, so its score is zero. Similarly, Z does not overlap any domains. The score of this method is the average domain score on all proteins, ~0.58, while the average number of domains per protein is 2. B. The y-axis is the number of predicted domains per protein ("signal"), while the x-axis is the ortholog coherence score (inversely related with "noise"), so better performing methods have higher curves (more signal for a given noise threshold). dPUC (green circles) outperforms the other methods. Symbols and colors are as in Figure 2.

Back to article page