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Table 1 Sample prediction results

From: An iterative approach of protein function prediction

Protein

Real Function

NC

Iteration

GO description

YGR285C

GO:0006417

GO:0006417

GO:0006417

Regulation of translation

 

GO:0006450

x

GO:0006450

Regulation of translational fidelity

 

GO:0006457

x

x

Protein folding

YGL022W

GO:0006486

x

GO:0006486

protein amino acid glycosylation

 

GO:0006487

GO:0006487

GO:0006487

protein amino acid N-linked glycosylation

 

GO:0018193

GO:0018193

GO:0018193

peptidyl-amino acid modification

 

GO:0009100

x

GO:0009100

glycoprotein metabolic process

YPR180W

GO:0006974

x

GO:0006974

response to DNA damage stimulus

 

GO:0008152

x

x

metabolic process

YKL181W

GO:0006015

GO:0006015

GO:0006015

5-phosphoribose 1-diphosphate biosynthetic process

 

GO:0009117

GO:0009117

GO:0009117

nucleotide metabolic process

 

GO:0009156

GO:0009156

GO:0009156

ribonucleoside monophosphate biosynthetic process

 

GO:0009165

GO:0009165

GO:0009165

nucleotide biosynthetic process

 

GO:0031505

GO:0031505

GO:0031505

fungal-type cell wall organization

 

GO:0043093

x

GO:0043093

cytokinesis by binary fission

YGL078C

GO:0006364

GO:0006364

GO:0006364

rRNA processing

 

GO:0000027

x

GO:0000027

ribosomal large subunit assembly

 

GO:0009451

x

x

RNA modification

YDR306C

GO:0006511

x

GO:0006511

ubiquitin-dependent protein catabolic process

YGR043C

GO:0005975

GO:0005975

GO:0005975

carbohydrate metabolic process

 

GO:0008152

GO:0008152

GO:0008152

metabolic process

 

GO:0006098

x

GO:0006098

pentose-phosphate shunt

 

GO:0006914

x

x

Autophagy

YJR140C

GO:0006350

GO:0006350

GO:0006350

Transcription

 

GO:0045449

GO:0045449

GO:0045449

regulation of transcription

 

GO:0006368

x

GO:0006368

RNA elongation from RNA polymerase II promoter

 

GO:0006336

x

x

DNA replication-independent nucleosome assembly

 

GO:0000083

x

x

regulation of transcription involved in G1/S phase of mitotic cell cycle

YLR086W

GO:0007076

GO:0007076

GO:0007076

mitotic chromosome condensation

 

GO:0007049

GO:0007049

GO:0007049

cell cycle

 

GO:0007067

GO:0007067

GO:0007067

Mitosis

 

GO:0051301

GO:0051301

GO:0051301

cell division

 

GO:0000070

GO:0000070

GO:0000070

mitotic sister chromatid segregation

 

GO:0030261

x

GO:0030261

chromosome condensation

 

GO:0070058

x

x

tRNA gene clustering

 

GO:0051276

x

x

chromosome organization

YJR065C

GO:0048308

GO:0048308

GO:0048308

organelle inheritance

 

GO:0007015

GO:0007015

GO:0007015

actin filament organization

 

GO:0000001

GO:0000001

GO:0000001

mitochondrion inheritance

 

GO:0030833

x

GO:0030833

regulation of actin filament polymerization

 

GO:0034314

x

x

Arp2/3 complex-mediated acting nucleation

  1. Note: X stands for a not-predicted function. These sample results show that the iterative approach predicted more correct functions than the non-iterative approach. For instance, the NC algorithm predicted only one correct function for protein YGR285C, while the iterative algorithm predicted two correct functions; the NC algorithms failed in predicting any correct functions for protein YPR180W, however one function was correctly predicted by the iterative algorithm.
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BMC Bioinformatics

ISSN: 1471-2105

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