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Figure 1 | BMC Bioinformatics

Figure 1

From: Context-dependent transcriptional regulations between signal transduction pathways

Figure 1

TRS Pathways relaying of a signal from TNF to NFKB. Each node represents a protein whose name follows the gene name. The color indicates its expression levels (fold change): red (≥ 3), orange (≥ 2 and < 3), yellow (≥ 1 and < 2), light yellow (≥ 0.5 and <1), white (> -0.5 and < 0.5), light cyan (> -1 and ≤ -0.5), cyan (> -2 and ≤ -1) and navy blue (> -3 and ≤ -2) and blue (≤ -3). The small UB and P circles represent ubiquitins and phosphates. (A) One of the known pathways from TNF to NFKB [35]. (B) In the KEGG TRS Pathway relaying a signal from TNF to NFKB, MAP3K1 (mekk1) is used as IKB kinase kinase (IKKK). (C) The omics network TRS Pathway seems to select each protein from its corresponding protein complex of (A) to make a linear path. The expression condition is 2h after the LPS treatment.

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