Table 1 The information of the three pathway patterns used in simulation
From: Pathway-based analysis using reduced gene subsets in genome-wide association studies
Pathway | # of total genes (SNPs) | # of assoc genes | # of causalSNPs | Minor Allele Frequency (MAF) | Estimate Relative Risk (ERR) |
|---|---|---|---|---|---|
TNFR2 Signaling Pathway (pattern 1) | 15 (159) | 2 | 4 | 0.340, 0.416, 0.298, 0.317 | 1.070, 1.081, 1.117, 1.130 |
Fructose and mannose metabolism (pattern 2) | 35 (339) | 4 | 6 | 0.163, 0.353, 0.359, 0.359, 0.424, 0.332 | 1.113, 1.077, 1.063, 1.101, 1.105, 1.088 |
Cytokine-cytokine receptor interaction (pattern 3) | 208 (1957) | 19 | 39 | 0.409, 0.491, 0.491, 0.275, 0.397, 0.315, 0.210, 0.073, 0.372, 0.415, 0.281, 0.219, 0.472, 0.305, 0.355, 0.435, 0.112, 0.323, 0.373, 0.044, 0.063, 0.227, 0.430, 0.070, 0.161, 0.355, 0.161, 0.034, 0.156, 0.417, 0.420, 0.169, 0.210, 0.175, 0.183, 0.269, 0.194, 0.177, 0.499 | 1.100, 1.065, 1.064, 1.090, 1.055, 1.086, 1.167, 1.172, 1.057, 1.084, 1.141, 1.081, 1.095, 1.149, 1.072, 1.092, 1.087, 1.062, 1.132, 1.134, 1.162, 1.094, 1.060, 1.247, 1.078, 1.062, 1.096, 1.249, 1.123, 1.070, 1.089, 1.073, 1.087, 1.093, 1.074, 1.064, 1.087, 1.123, 1.071 |