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Figure 8 | BMC Bioinformatics

Figure 8

From: OrthoInspector: comprehensive orthology analysis and visual exploration

Figure 8

OrthoInspector graphical interface. The graphical interface provides visualization tools allowing a global view of the selected data. A. The advanced query interface allows selection of orthology/inparalogy relationships based on presence/absence criteria (pres. = presence, abs. = absence, uncar. = uncaring). B. Graph-based visualization of selected relationships. C. Presence/absence diagrams resume the repartition of orthologs/inparalogs for a family of proteins. Here, the human myotubularin-related protein 6 (mtmr6, Q9Y217) was used as the query. No orthology relationship is found in P. falciparum, a 1-to-1 ortholog is found in M. musculus (Q8VE11) and a 1-to-many relationship involving four co-orthologs is found in E. hystolitica (XP_653520; XP_654089; XP_648834; XP_655157). These sequences are then used as query to find potentially new sequences of the family in these organisms. Here sequences of E. histolytica make a 1-to-many relation with the seven human myotubularins and the six mouse myotubularins (these ones are inparalogs relative to entamoeba histolytica). Here are only represented the human MTMR7 (Q9Y216) and MTMR8 (Q96EF0) and the murine MTMR7 (Q9Z2C9).

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