Figure 7
From: BiologicalNetworks 2.0 - an integrative view of genome biology data
Integrated molecular interaction network of human/mouse/rat hypertension. Red rectangles - highly co-expressed (red lines) and over-expressed genes in hypertension. Yellow triangles - TFs potentially regulating hypertension-specific genes, which TF binding sites are conserved in human, mouse and rat. Black lines - physical protein/TF/kinase - protein/TF/kinase interactions. Green and Blue squares - genes/proteins/TFs that are well known from literature to be essential in hypertension. Red lines - co-expressed genes/proteins. Dashed lines - predicted TFs and their target genes. Numbers (1-4) correspond to gene/protein groups functionally enriched by particular GO terms, shown in the upper left corner.