Figure 1
From: Content-based microarray search using differential expression profiles
Schematic diagram of our approach. (A) Creation of differential expression (DE) profiles. An experiment comparing condition X with condition Y is condensed to a single DE profile in gene space. Dimension reduction is applied to create a DE profile in a reduced feature space. (B) Searching a library of DE profiles. The query profile is compared to the DE profiles of all other experiments in our disease compendium (or in GEO) using a similarity measure. Results are ranked by their similarity to the query profile. Italics indicate variable steps in our pipeline.